People often mistakenly refer to Trisomy 21 (the medical term) as Downs Syndrome. Not so. It is Down, like Up. Trisomy 21 (Down Syndrome) is named after Dr. John Langdon Down who in 1866 described the condition as a distinct set of characteristics.
Make no mistake about it, “down” does not describe someone inferior, unhappy, depressed or less than. It simply refers to a man’s last name.